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Description
Stat5b Recombinant Rabbit mAb (S-2951-34)Product Specification Host Rabbit Antigen Stat5b Synonyms Signal transducer and activator of transcription 5B Immunogen Recombinant Protein Location Cytoplasm, Nucleus Accession P42232 Clone Number S 2951 34 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample K562, HeLa, Jurkat, Raji, Daudi, NIH 3T3, RAW264. 7, mouse heart, PC 12, rat heart Purification Protein A Concentration 0. 5 mg ml
Product Specification
| Host | Rabbit |
| Antigen | Stat5b |
| Synonyms | Signal transducer and activator of transcription 5B |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Nucleus |
| Accession | P42232 |
| Clone Number | S-2951-34 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | K562, HeLa, Jurkat, Raji, Daudi, NIH/3T3, RAW264.7, mouse heart, PC-12, rat heart |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu, Ms, Rt |
| IHC-P | 1:2000 | Hu, Ms, Rt |
| ICC | 1:500 | Ms |
Background
Stat5b (signal transducer and activator of transcription 5b) is a 787-amino-acid transcription factor that, upon phosphorylation by JAK kinases in response to cytokines such as IL-2, GH, prolactin or IFN-α, dimerizes and translocates to the nucleus where it binds the consensus GAS motif TTCNNNGAA to regulate genes controlling cell survival, proliferation, differentiation and metabolic reprogramming; it is indispensable for normal immune homeostasis, mammary gland development and liver GH signaling, and its persistent activation is a driver of multiple hematologic and solid cancers, making Stat5b a validated therapeutic target.
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